Insulin glargine placental transfer Insulin Glargine Safety in Pregnancy: a Transplacental Transfer Study Short Title: Insulin glargine placental transfer
نویسندگان
چکیده
1 Division of Clinical Pharmacology and Toxicology, the Hospital for Sick Children, Toronto, Ontario, Canada, 2 Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada, 3 Division of Endocrinology, Mount Sinai Hospital, Department of Medicine, University of Toronto, Toronto, Ontario, Canada, and 4 Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
منابع مشابه
Insulin Glargine Safety in Pregnancy
OBJECTIVE Insulin glargine (Lantus) is an extended-action insulin analog with greater stability and duration of action than regular human insulin. The long duration of action and decreased incidence of hypoglycemia provide potential advantages for its use in pregnancy. However, the placental pharmacokinetics of insulin glargine have not been studied. Therefore, the objective of this study was t...
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OBJECTIVE: Hyperglycemia is associated with increased morbidity and mortality in diabetic patients following coronary artery bypass grafting. Tight glycemic control in perioperative period can reduce these events. The goal of this study was to determine whether combination of continuous infusion and subcutaneous glargine as a basal insulin could improve glycemic control. MATERIAL AND METHODS:...
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Objective(s): The mitogenic effect of the analogous insulin glargine is currently under debate since several clinical studies have raised the possibility that insulin glargine treatment has a carcinogenic potential in different tissues. This study aimed to evaluate the Igf-1r, Insr, and Igf-1 gene expression in colon and liver of streptozotocin-induced diabetic rats in response to insulin glarg...
متن کاملCleveland Clinic cardiovascular intensive care unit insulin conversion protocol.
BACKGROUND The importance of near-normal blood glucose in the immediate postoperative period is generally accepted and is best achieved in the perioperative period with a constant intravenous (IV) infusion of insulin. This requires intensive nursing only achievable in an intensive care unit (ICU) setting. Glucose management after transfer to a regular nursing floor (RNF) has not been studied sy...
متن کاملThe modified recombinant proinsulin: a simple and efficient route to produce insulin glargine in E. coli
Background: Recombinant insulin glargine, a long-acting analogue of insulin, is expressed as proinsulin in host cell and after purification and refolding steps cleaved to active insulin by enzymatic digestion using trypsin and carboxypeptidase B. Since the proinsulin's B and C chains have several internal arginine and lysine residues, a number of impurities are generated following treatment wit...
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تاریخ انتشار 2009